[pygr-notify] Issue 44 in pygr: tblastn and blastx support
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codesite-noreply at google.com
Thu Dec 18 14:33:11 PST 2008
Comment #1 on issue 44 by cjlee112: tblastn and blastx support
http://code.google.com/p/pygr/issues/detail?id=44
Another possibility:
- since tblastn and blastx return protein-protein alignments, it might be
more
intuitive for users to get back this protein-protein alignment. One of the
two
aligned protein sequences (dest for tblastn, and src for blastx) would be a
translation of the actual database sequence (nucleotide sequence). We
could model
this protein sequence as an annotation whose sequence attribute would
correspond to
the nucleotide sequence interval that encodes it.
- This is pretty easy to implement, because the process_blast() method
takes a
database argument for retrieving each sequence ID. That database could be
an
annotation db created specifically for translations.
- Question: how exactly to handle the coordinates returned by BLAST?
Whereas it
returns a protein sequence, it gives nucleotide coordinates... That
implies a bit
more work.
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