[metagenomics-jclub] "Statistical Methods for Analysis of Gut Microbiome Data" seminar

[Fan Yang]

It seems like an interesting one. It's on Thursday April 26th, 1pm in room
E4 Fee Hall. Details see beneath.

Fan

---------- Forwarded message ----------
From: Terence L. Marsh <marsht at msu.edu>
Date: Mon, Apr 23, 2012 at 4:38 PM
Subject: Fwd: Hongzhe Li seminar
To: Fan Yang <yangfan1 at egr.msu.edu>, Masanori Fujimoto <
masafujimot2 at gmail.com>


 This seminar might be interesting from a statistical point of view.

-------- Original Message --------  Subject: Hongzhe Li seminar  Date: Mon,
23 Apr 2012 16:13:48 -0400  From: Claudia Holzman
<holzman at epi.msu.edu><holzman at epi.msu.edu>  To:
Terence Marsh <marsht at msu.edu> <marsht at msu.edu>

 Hi Terry, ****

Our research group is scheduled to meet this Thursday, April 26 with the
Epi Speaker, Hongzhe Li ( see below, seminar at 4PM) at 1PM here at
6thFloor Fee. Are you interested in joining in?
****

** **

Also please alert any of your colleagues who may want to attend the seminar.
****

Thanks,****

Claudia****

** **

Claudia Holzman, D.V.M, M.P.H, Ph.D.****

Professor and Chair of the Department of Epidemiology and Biostatistics****

College of Human Medicine****

646 West Fee Hall****

Michigan State University****

East Lansing, Michigan 48824****

** **

Telephone: (517) 353-8623****

Fax: (517) 432-1130****

Email: Holzman at msu.edu****

** **

** **

*From:* Nancy Bieber
*Sent:* Monday, April 23, 2012 2:42 PM
*To:* Nancy Bieber
*Subject:* Hongzhe Li seminar lunch and talk Thurs April 26
*Importance:* High****

** **

*Please don’t forget to RSVP so we know how much pizza to order! - Nancy*

** **

** **


Dear Epi students, postdocs and faculty,
Hongzhe Li,  Professor of Biostatistics in Biostatistics and Epidemiology,
U of Pennysylvania, will visit MSU to present an Epi departmental seminar
on "Statistical Methods for Analysis of Gut Microbiome Data” on Thursday
April 26th 4:00 p.m. E4 Fee Hall.

BACKGROUND READING: Dr Li has suggested the Science paper "Linking
Long-Term Dietary Patterns with Gut Microbial Enterotypes" at
http://www.sciencemag.org.proxy2.cl.msu.edu/content/334/6052/105.full?sid=02312a38-abd2-48f9-bf47-6404913434b2

LUNCH:  We scheduled a pizza and fruit lunch for students and faculty for
informal discussion with Dr Li in the Central Conference room at 11:45 AM.
Please send Nancy your RSVP if you will participate in the lunch!
Thanks,
Madeleine


"Statistical Methods for Analysis of Gut Microbiome Data"
Abstract:
With the development of next generation sequencing technology, researchers
have now been able to study the microbiome composition using direct
sequencing, whose output are taxa counts for each microbiome sample. One
goal of microbiome study is to associate the microbiome composition with
environmental covariates. In some cases, we may have a large number of
covariates and identification of the relevant covariates and their
associated bacterial taxa becomes important. In this talk, I present
several statistical methods for analysis of the human microbiome data,
including exploratory analysis methods such as generalized
UniFrac distances and graph-constrained canonical correlations and
statistical models for the count data and simplex data. In particular, I
present a sparse group variable selection method for Dirichlet-multinomial
regression to account for overdispersion of the counts  and to impose a
sparse group L1 penalty to encourage both group-level  and within-group
sparsity. I demonstrate the application of these methods
with an on-going human gut microbiome study to investigate the association
between nutrient intake and  microbiome composition. Finally, I present
several challenging  statistical and computational problems in analysis of
shotgun metagenomics data.

****

** **
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