<div class="gmail_extra">It seems like an interesting one. It's on Thursday April 26th, 1pm in room E4 Fee Hall. Details see beneath. </div><div class="gmail_extra"><br></div><div class="gmail_extra">Fan<br><br><div class="gmail_quote">
---------- Forwarded message ----------<br>From: <b class="gmail_sendername">Terence L. Marsh</b> <span dir="ltr"><<a href="mailto:marsht@msu.edu">marsht@msu.edu</a>></span><br>Date: Mon, Apr 23, 2012 at 4:38 PM<br>
Subject: Fwd: Hongzhe Li seminar<br>To: Fan Yang <<a href="mailto:yangfan1@egr.msu.edu">yangfan1@egr.msu.edu</a>>, Masanori Fujimoto <<a href="mailto:masafujimot2@gmail.com">masafujimot2@gmail.com</a>><br><br>
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This seminar might be interesting from a statistical point of view.<br>
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<th align="RIGHT" nowrap valign="BASELINE">Subject: </th>
<td>Hongzhe Li seminar</td>
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<th align="RIGHT" nowrap valign="BASELINE">Date: </th>
<td>Mon, 23 Apr 2012 16:13:48 -0400</td>
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<th align="RIGHT" nowrap valign="BASELINE">From: </th>
<td>Claudia Holzman <a href="mailto:holzman@epi.msu.edu" target="_blank"><holzman@epi.msu.edu></a></td>
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<th align="RIGHT" nowrap valign="BASELINE">To: </th>
<td>Terence Marsh <a href="mailto:marsht@msu.edu" target="_blank"><marsht@msu.edu></a></td>
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<p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif"">Hi
Terry, <u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif"">Our
research group is scheduled to meet this Thursday, April 26
with the Epi Speaker,</span><span style="font-size:14.0pt"> Hongzhe Li ( see below,
seminar at 4PM) at 1PM here at 6<sup>th</sup> Floor Fee. Are
you interested in joining in?<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Also
please alert any of your colleagues who may want to attend the
seminar.<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Thanks,<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Claudia</span><span style="font-size:14.0pt;font-family:"Calibri","sans-serif""><u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<div>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Claudia
Holzman, D.V.M, M.P.H, Ph.D.<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Professor
and Chair of the Department of Epidemiology and
Biostatistics<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">College
of Human Medicine<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">646
West Fee Hall<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Michigan
State University<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">East
Lansing, Michigan 48824<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Telephone:
<a href="tel:%28517%29%20353-8623" value="+15173538623" target="_blank">(517) 353-8623</a><u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Fax:
<a href="tel:%28517%29%20432-1130" value="+15174321130" target="_blank">(517) 432-1130</a><u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Email:
<a href="mailto:Holzman@msu.edu" target="_blank">Holzman@msu.edu</a></span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1f497d"><u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
</div>
<p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif";color:#1f497d"><u></u> <u></u></span></p>
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<div style="border:none;border-top:solid #b5c4df 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">
Nancy Bieber <br>
<b>Sent:</b> Monday, April 23, 2012 2:42 PM<br>
<b>To:</b> Nancy Bieber<br>
<b>Subject:</b> Hongzhe Li seminar lunch and talk Thurs
April 26<br>
<b>Importance:</b> High<u></u><u></u></span></p>
</div>
</div>
<p class="MsoNormal"><u></u> <u></u></p>
<p class="MsoNormal"><b><span style="color:red">Please don’t
forget to RSVP so we know how much pizza to order! - Nancy<u></u><u></u></span></b></p>
<p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif""><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif""><u></u> <u></u></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><br>
Dear Epi students, postdocs and faculty,<br>
Hongzhe Li, Professor of Biostatistics in Biostatistics and
Epidemiology, U of Pennysylvania, will visit MSU to present an
Epi departmental seminar on "Statistical Methods for Analysis of
Gut Microbiome Data” on Thursday April 26th 4:00 p.m. E4 Fee
Hall.<br>
<br>
BACKGROUND READING: Dr Li has suggested the Science paper
"Linking Long-Term Dietary Patterns with Gut Microbial
Enterotypes" at<br>
<a href="http://www.sciencemag.org.proxy2.cl.msu.edu/content/334/6052/105.full?sid=02312a38-abd2-48f9-bf47-6404913434b2" target="_blank">http://www.sciencemag.org.proxy2.cl.msu.edu/content/334/6052/105.full?sid=02312a38-abd2-48f9-bf47-6404913434b2</a>
<br>
<br>
LUNCH: We scheduled a pizza and fruit lunch for students and
faculty for informal discussion with Dr Li in the Central
Conference room at 11:45 AM. Please send Nancy your RSVP if you
will participate in the lunch!<br>
Thanks,<br>
Madeleine<br>
<br>
<br>
<tt><span style="font-size:10.0pt">"Statistical Methods for
Analysis of Gut Microbiome Data"</span></tt><span style="font-size:10.0pt;font-family:"Courier New""><br>
<tt>Abstract:</tt><br>
<tt>With the development of next generation sequencing
technology, researchers have now been able to study the
microbiome composition using direct sequencing, whose output
are taxa counts for each microbiome sample. One goal of
microbiome study is to associate the microbiome composition
with environmental covariates. In some cases, we may have a
large number of covariates and identification of the
relevant covariates and their associated bacterial taxa
becomes important. In this talk, I present several
statistical methods for analysis of the human microbiome
data, including exploratory analysis methods such as
generalized</tt><br>
<tt>UniFrac distances and graph-constrained canonical
correlations and statistical models for the count data and
simplex data. In particular, I present a sparse group
variable selection method for Dirichlet-multinomial</tt><br>
<tt>regression to account for overdispersion of the counts
and to impose a sparse group L1 penalty to encourage both
group-level and within-group sparsity. I demonstrate the
application of these methods</tt><br>
<tt>with an on-going human gut microbiome study to investigate
the association between nutrient intake and microbiome
composition. Finally, I present several challenging
statistical and computational problems in analysis of
shotgun metagenomics data.</tt><br>
<br>
</span><u></u><u></u></p>
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