<html><head><meta http-equiv="Content-Type" content="text/html charset=us-ascii"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><br><div><br><div>Begin forwarded message:</div><br class="Apple-interchange-newline"><blockquote type="cite"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;"><span style="font-family:'Helvetica'; font-size:medium; color:rgba(0, 0, 0, 1.0);"><b>From: </b></span><span style="font-family:'Helvetica'; font-size:medium;">NGSCourse 2014 <<a href="mailto:noreply@snubi.org">noreply@snubi.org</a>><br></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;"><span style="font-family:'Helvetica'; font-size:medium; color:rgba(0, 0, 0, 1.0);"><b>Subject: </b></span><span style="font-family:'Helvetica'; font-size:medium;"><b>Analysis of Next Generation Sequence Data Course June 23-27, 2014 Berlin</b><br></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;"><span style="font-family:'Helvetica'; font-size:medium; color:rgba(0, 0, 0, 1.0);"><b>Date: </b></span><span style="font-family:'Helvetica'; font-size:medium;">April 23, 2014 2:05:29 PM EDT<br></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;"><span style="font-family:'Helvetica'; font-size:medium; color:rgba(0, 0, 0, 1.0);"><b>To: </b></span><span style="font-family:'Helvetica'; font-size:medium;"><a href="mailto:titus@caltech.edu">titus@caltech.edu</a><br></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;"><span style="font-family:'Helvetica'; font-size:medium; color:rgba(0, 0, 0, 1.0);"><b>Reply-To: </b></span><span style="font-family:'Helvetica'; font-size:medium;">NGSCourse 2014 <<a href="mailto:noreply@snubi.org">noreply@snubi.org</a>><br></span></div><br>
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<h1 style="margin:0in 0in 0.0001pt;text-align:center" align="center"><span style="color:rgb(0,0,139)">Analysis of
Next Generation Sequence Data Course</span></h1>
<h1 style="margin:0in 0in 0.0001pt;text-align:center" align="center"><span style="color:rgb(0,0,139)">For Complex
and Mendelian Traits </span></h1>
<h2 style="margin:0in 0in 0.0001pt;text-align:center" align="center"><span style="color:rgb(0,0,139)">June 23-27,
2014<br>
Max Delbrck Center (MDC) for Molecular Medicine<br>
Berlin, Germany</span></h2>
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</div><p><span style="font-size:13.5pt">The Analysis of Next Generation
Sequence Data
Course will be held at the MDC in Berlin from June 23-27, 2014.
The goal of the course is to teach the course
participants both the theory and application of methods to
analyze next
generation sequence (NGS) data for human traits. Attendees will
learn how to design studies,
call variants from NGS data, analyze population- and
family-based sequence data
and evaluate variant functionality.
Analyses will include performing complex trait rare variant
association
analysis for population and trio data and also identifying
variants for
Mendelian traits. Exercises will be
carried out using a variety of computer programs (GATK, IGV,
Polyphen2, PSEQ,
SEQPower, and Variant Association Tools (VAT)). TOPICS will be
include:
sequence alignment, calling variants from NGS data, population
genetics
(purifying selection, drift, etc), quality control of NGS data,
association
testing framework for quantitative and qualitative traits, rare
variant
association methods, estimating power and sample size for rare
variant
association tests, imputation of rare variants, detecting
putative causal
variants for Mendelian traits and evaluating variant
functionality. The
instructors for the course are Laurent Francioli (<span style="background-repeat:initial initial">University Medical
Center Utrecht</span>), Suzanne Leal(Baylor
College of Medicine), Michael Nothnagel(University of Cologne)
and Peter Robinson(Charit).</span></p><p><span style="font-size:13.5pt">For additional Information, course
schedule and application form please visit the course website</span></p><p><font size="4"><a href="https://www.bcm.edu/departments/molecular-and-human-genetics/leal/ngscourse2014">https://www.bcm.edu/departments/molecular-and-human-genetics/leal/ngscourse2014</a></font><br>
</p><p><span style="font-size:13.5pt">Application deadline May 15, 2014</span></p><p><span style="font-size:13.5pt"><br>
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