<html><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; ">actually the seminar is at 4PM in fee<div><br></div><div><br><div apple-content-edited="true"> <span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; font-size: medium; "><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; font-size: medium; "><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; font-size: medium; "><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; font-size: medium; "><div>Terence L. Marsh, Ph.D.</div><div>Department of Microbiology and Molecular Genetics</div><div>2209 Biomedical & Physical Sciences</div><div>Michigan State University</div><div>East Lansing, MI 48824</div><div>Office - 517-884-5391</div><div>Lab - 517-884-5382</div><div><a href="mailto:marsht@msu.edu">marsht@msu.edu</a></div><div><br></div><br class="Apple-interchange-newline"><br class="Apple-interchange-newline"></span></span></div></span></div></span> </div><br><div><div>On Apr 23, 2012, at 8:54 PM, Fan Yang wrote:</div><br class="Apple-interchange-newline"><blockquote type="cite"><div class="gmail_extra">It seems like an interesting one. It's on Thursday April 26th, 1pm in room E4 Fee Hall. Details see beneath. </div><div class="gmail_extra"><br></div><div class="gmail_extra">Fan<br><br><div class="gmail_quote"> ---------- Forwarded message ----------<br>From: <b class="gmail_sendername">Terence L. Marsh</b> <span dir="ltr"><<a href="mailto:marsht@msu.edu">marsht@msu.edu</a>></span><br>Date: Mon, Apr 23, 2012 at 4:38 PM<br> Subject: Fwd: Hongzhe Li seminar<br>To: Fan Yang <<a href="mailto:yangfan1@egr.msu.edu">yangfan1@egr.msu.edu</a>>, Masanori Fujimoto <<a href="mailto:masafujimot2@gmail.com">masafujimot2@gmail.com</a>><br><br> <br> <div bgcolor="#FFFFFF" text="#000000"> This seminar might be interesting from a statistical point of view.<br> <br> -------- Original Message -------- <table border="0" cellpadding="0" cellspacing="0"> <tbody> <tr> <th align="RIGHT" nowrap="" valign="BASELINE">Subject: </th> <td>Hongzhe Li seminar</td> </tr> <tr> <th align="RIGHT" nowrap="" valign="BASELINE">Date: </th> <td>Mon, 23 Apr 2012 16:13:48 -0400</td> </tr> <tr> <th align="RIGHT" nowrap="" valign="BASELINE">From: </th> <td>Claudia Holzman <a href="mailto:holzman@epi.msu.edu" target="_blank"><holzman@epi.msu.edu></a></td> </tr> <tr> <th align="RIGHT" nowrap="" valign="BASELINE">To: </th> <td>Terence Marsh <a href="mailto:marsht@msu.edu" target="_blank"><marsht@msu.edu></a></td> </tr> </tbody> </table> <br> <br> <div><p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif"">Hi Terry, <u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif"">Our research group is scheduled to meet this Thursday, April 26 with the Epi Speaker,</span><span style="font-size:14.0pt"> Hongzhe Li ( see below, seminar at 4PM) at 1PM here at 6<sup>th</sup> Floor Fee. Are you interested in joining in?<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:14.0pt"><u></u> <u></u></span></p><p class="MsoNormal"><span style="font-size:14.0pt">Also please alert any of your colleagues who may want to attend the seminar.<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:14.0pt">Thanks,<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:14.0pt">Claudia</span><span style="font-size:14.0pt;font-family:"Calibri","sans-serif""><u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif";color:#1f497d"><u></u> <u></u></span></p> <div><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Claudia Holzman, D.V.M, M.P.H, Ph.D.<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Professor and Chair of the Department of Epidemiology and Biostatistics<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">College of Human Medicine<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">646 West Fee Hall<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Michigan State University<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">East Lansing, Michigan 48824<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d"><u></u> <u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Telephone: <a href="tel:%28517%29%20353-8623" value="+15173538623" target="_blank">(517) 353-8623</a><u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Fax: <a href="tel:%28517%29%20432-1130" value="+15174321130" target="_blank">(517) 432-1130</a><u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:#1f497d">Email: <a href="mailto:Holzman@msu.edu" target="_blank">Holzman@msu.edu</a></span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1f497d"><u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1f497d"><u></u> <u></u></span></p> </div><p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif";color:#1f497d"><u></u> <u></u></span></p> <div> <div style="border:none;border-top:solid #b5c4df 1.0pt;padding:3.0pt 0in 0in 0in"><p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> Nancy Bieber <br> <b>Sent:</b> Monday, April 23, 2012 2:42 PM<br> <b>To:</b> Nancy Bieber<br> <b>Subject:</b> Hongzhe Li seminar lunch and talk Thurs April 26<br> <b>Importance:</b> High<u></u><u></u></span></p> </div> </div><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal"><b><span style="color:red">Please don’t forget to RSVP so we know how much pizza to order! - Nancy<u></u><u></u></span></b></p><p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif""><u></u> <u></u></span></p><p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Calibri","sans-serif""><u></u> <u></u></span></p><p class="MsoNormal" style="margin-bottom:12.0pt"><br> Dear Epi students, postdocs and faculty,<br> Hongzhe Li, Professor of Biostatistics in Biostatistics and Epidemiology, U of Pennysylvania, will visit MSU to present an Epi departmental seminar on "Statistical Methods for Analysis of Gut Microbiome Data” on Thursday April 26th 4:00 p.m. E4 Fee Hall.<br> <br> BACKGROUND READING: Dr Li has suggested the Science paper "Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes" at<br> <a href="http://www.sciencemag.org.proxy2.cl.msu.edu/content/334/6052/105.full?sid=02312a38-abd2-48f9-bf47-6404913434b2" target="_blank">http://www.sciencemag.org.proxy2.cl.msu.edu/content/334/6052/105.full?sid=02312a38-abd2-48f9-bf47-6404913434b2</a> <br> <br> LUNCH: We scheduled a pizza and fruit lunch for students and faculty for informal discussion with Dr Li in the Central Conference room at 11:45 AM. Please send Nancy your RSVP if you will participate in the lunch!<br> Thanks,<br> Madeleine<br> <br> <br> <tt><span style="font-size:10.0pt">"Statistical Methods for Analysis of Gut Microbiome Data"</span></tt><span style="font-size:10.0pt;font-family:"Courier New""><br> <tt>Abstract:</tt><br> <tt>With the development of next generation sequencing technology, researchers have now been able to study the microbiome composition using direct sequencing, whose output are taxa counts for each microbiome sample. One goal of microbiome study is to associate the microbiome composition with environmental covariates. In some cases, we may have a large number of covariates and identification of the relevant covariates and their associated bacterial taxa becomes important. In this talk, I present several statistical methods for analysis of the human microbiome data, including exploratory analysis methods such as generalized</tt><br> <tt>UniFrac distances and graph-constrained canonical correlations and statistical models for the count data and simplex data. In particular, I present a sparse group variable selection method for Dirichlet-multinomial</tt><br> <tt>regression to account for overdispersion of the counts and to impose a sparse group L1 penalty to encourage both group-level and within-group sparsity. I demonstrate the application of these methods</tt><br> <tt>with an on-going human gut microbiome study to investigate the association between nutrient intake and microbiome composition. Finally, I present several challenging statistical and computational problems in analysis of shotgun metagenomics data.</tt><br> <br> </span><u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p> </div> </div> </div><br></div> _______________________________________________<br>metagenomics-jclub mailing list<br><a href="mailto:metagenomics-jclub@lists.idyll.org">metagenomics-jclub@lists.idyll.org</a><br>http://lists.idyll.org/listinfo/metagenomics-jclub<br></blockquote></div><br></div></body></html>